Laura Kaijanen

This dissertation focuses on the analytics for the products from the renewable resources, especially the validation and development of capillary electrophoretic methods.

The aim of the study is to develop and validate CE methods for the monitoring of the process streams of bioprocesses. One of the aims is to evaluate suitability of the method for the identification and quantification of the compounds, focusing mainly in the wood-based materials. The aim is also to find new applications for the side streams of the separation processes of biorefining.

In this research, the suitability and applicability of the methods for monitoring of biorefining in forest industry are studied. The bases of validation procedures are adapted from the traditional analytical methods. In the evaluation of suitability also real process samples are analyzed, which emphasizes the purpose of validation. The suitability for industrial applications is also discussed from the environmental point of view.

The procedure of in-house validation is studied at general level of metrology from both scientific and industrial point of views. E.g. selectivity, specificity, linearity, and limits for detection and quantitation are evaluated. Also the requirements for the equipment in the industrial environment are discussed.